Wednesday, October 31, 2012

Eurozone unemployment rises to new record

A man begs for alms in a street, in Pamplona, northern Spain, Tuesday, Oct. 30, 2012. Spain's National Statistics Institute says Tuesday that the country's economy contracted 0.3 percent in the third quarter from the previous three month period. Spain is in a double-dip recession and has a 25 percent unemployment rate. Prime Minister Mariano Rajoy said Monday the country has no immediate need to ask for outside aid to help deal with its debts. (AP Photo/Alvaro Barrientos)

A man begs for alms in a street, in Pamplona, northern Spain, Tuesday, Oct. 30, 2012. Spain's National Statistics Institute says Tuesday that the country's economy contracted 0.3 percent in the third quarter from the previous three month period. Spain is in a double-dip recession and has a 25 percent unemployment rate. Prime Minister Mariano Rajoy said Monday the country has no immediate need to ask for outside aid to help deal with its debts. (AP Photo/Alvaro Barrientos)

(AP) ? Unemployment in the 17-country eurozone rose to a record 11.6 percent in September, official figures showed Wednesday, in another grim development for a region that is struggling to get to grips with a three-year debt crisis.

The rate reported by Eurostat, the EU's statistics office, is up from an upwardly-revised 11.5 percent in August. In total, 18.49 million people were out of work in the eurozone in September, up 146,000 on the previous month.

While the eurozone's unemployment rate has been rising steadily for the past year as its economy struggled, the United States has seen its equivalent rate fall to 7.8 percent. The latest U.S. figures are due this Friday.

Five countries in the eurozone are already in recession ? Greece, Spain, Italy, Portugal, and Cyprus. The region as a whole is expected to be confirmed to be in recession when the first estimate of eurozone economic activity in the third quarter is published mid-November ? a recession is officially confirmed after two consecutive quarters of negative growth.

Spain was in the ignominious position of having the highest unemployment rate in the eurozone, at 25.8 percent. However, Greece was not far behind at 25.1 percent, though its figure relates to July.

Both countries, which are at the epicenter of Europe's three-year debt crisis, have youth unemployment above 50 percent.

The lowest unemployment rate in the eurozone was Austria's 4.4 percent. Germany, Europe's biggest economy, has a jobless rate of only 5.4 percent.

Separately, Eurostat reported that inflation in the eurozone fell modestly to 2.5 percent in the year to October, from the previous month's 2.6 percent. Inflation is still above the European Central Bank's target of keeping price rises just below 2 percent.

Above-target inflation has not prevented the ECB cutting its key interest rate to a record low of 0.75 percent, but few economists think the bank will lower borrowing costs at next Thursday's monthly meeting.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/f70471f764144b2fab526d39972d37b3/Article_2012-10-31-EU-Europe-Economy/id-d03da5c12b094e58bb1402d2015cbfda

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Early voting extended in Maryland, Washington D.C. after storm (reuters)

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Monday, October 29, 2012

Home sweet home: nesting in the White House

Reagan Presidential Library

President and Nancy Reagan sometimes ate on TV trays in the White House residence.

By Mary Boone, Zillow

Leading a nation is tough work. When the president of the United States goes to his private residence at the end of the day, he undoubtedly yearns for the comforts of ?home.? But what does that home look like?

The second floor of the White House is the first family?s residence, where their bedrooms and private sitting rooms are located. This level has 16 rooms?? including the Lincoln bedroom?? one main corridor and six bathrooms. Every first family undertakes minor redecorating and restoration work when they move into the White House.

Privacy preferences
Some presidents have been less private than others when it comes to the private residence. The Clintons, for example, hosted official events there, and first lady Laura Bush allowed documentary crews to film her White House home.

President Barack Obama and first lady Michelle Obama, on the other hand, have worked to ensure the family space is for family only. Journalist Jodi Kantor, whose book "The Obamas" was released in August, has been in the White House dozens of times but has never been to the family?s private quarters.

?I can?t even name a journalist who has ever been up there under the Obama watch,? she told Chicago Magazine. ?The Obama attitude with the private quarters is, ?This is Sasha and Malia?s home.? ?

What is known about the Obamas' D.C. home is that they entrusted its d?cor to California-based interior designer Michael S. Smith, whose celebrity clients include Steven Spielberg, Dustin Hoffman and Rupert Murdoch. Smith has remained tight-lipped about the Obamas' specific style, noting only that ?the couple?s interest in bringing 20th-century American artists to the forefront and utilizing affordable brands and products? would serve as his work?s guiding principles.

Jimmy Carter Library

President Jimmy Carter watches his daughter, Amy, and grandson, Jason, play in Amy's tree house on the South Lawn.

While no formal pictures of the rooms in the private quarters have been released in the past four years, much is known about changes the Obamas have made on the White House grounds. Michelle Obama?s kitchen garden has been widely publicized, and first daughters Malia and Sasha are enjoying a wooden swing set?? complete with tree house, tire swing and climbing wall?? installed for them on the South Lawn.

Presidential administrations have all left their marks on the White House. Some of the most notable updates thorough the years:

Presidential pool
In 1933, citizens raised money to build a White House swimming pool for President Franklin D. Roosevelt, who suffered from the crippling disease poliomyelitis.

Roosevelt used the pool, located inside the west gallery between the White House and the West Wing, multiple times each day. In later years, President Harry Truman swam in it frequently. President John F. Kennedy liked the pool so much that he made a habit of stopping by at lunch, stripping down for a swim and sneaking back to his private quarters for a nap wearing nothing but a robe.

In 1970, the increasing demand for TV news coverage created the need for a media workspace within the White House. President Richard Nixon had the pool filled in and ordered the construction of a press room in its place.

With no indoor pool available, President Gerald Ford decided to have an in-ground pool constructed on the White House grounds in 1975; he swam daily when in town, and his son, Jack, took scuba lessons in the pool. President Jimmy Carter?s young daughter Amy and first lady Barbara Bush both used the pool on a regular basis.

Pitch perfect
President Truman created a horseshoe pitch just off the Oval Office, but it was later removed. President George H.W. Bush had a new one constructed near the White House swimming pool. He introduced several world leaders to the sport, including Soviet leader Mikhail Gorbachev and Queen Elizabeth II of England.

Bowling and golf
Bowling lanes were first built in the ground floor of the West Wing as a birthday gift for President Truman in 1947. Truman didn't care for bowling himself but allowed his staff to start a league. These were moved to the Old Executive Office Building in 1955 to make way for a mimeograph room.

In 1969, President and Mrs. Nixon, both avid bowlers, had a new one-lane alley built in an underground work space area below the driveway leading to the North Portico.

President Dwight D. Eisenhower had a putting green installed at the White House in 1954. President Bill Clinton had the putting green moved to its present location, just outside the Oval Office door, in 1995. The two greens have been well-used over the years, helping to perfect the putts of Presidents Ford, Johnson, Nixon, Reagan, George H.W. Bush, George W. Bush and Obama.

Getting the runaround
President Clinton had a running track installed on the South Lawn of the White House. Much to the dismay of the Secret Service, Clinton preferred jogging around the streets of Washington, D.C. ? often disrupting traffic ? rather than running on the secure White House path. The track has since been removed.

Child?s play
The Obamas aren?t the first presidential parents who?ve added White House play structures for the benefit of their children. First lady Jacqueline Kennedy had a trampoline built into the ground so that Caroline and John Jr. were not visible to pedestrians as the pair bounced into the air. President Carter helped design and build a tree house for daughter Amy on the White House grounds.

More from Zillow:

Source: http://bottomline.nbcnews.com/_news/2012/10/28/14667372-home-sweet-home-each-president-adds-own-touch-to-white-house?lite

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Thursday, October 25, 2012

Re: Merge new unsourced tree with new sources - Family Tree ...

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Source: http://boards.ancestry.co.uk/topics.software.famtreemaker/9077.1.1.1.1.1.1/mb.ashx

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How to ditch your debt before the holidays

By Andrew Housser

Picking out the perfect holiday present for loved ones can fun. Yet, it's painful if the sting of holiday overspending lingers into the next year. If you still remember (or feel) the financial pinch from charges you racked up during last year's Black Friday, follow these strategies and ditch that debt before this holiday season is in full swing.

1. Come up with a payment plan.

It feels great to pay off a debt, regardless of how small the amount. Start by putting as much as you can toward your smallest debt while making minimum payments on all others. Once that small debt's gone, add the amount you were paying on it to the minimum you have been paying on the next smallest debt until it is paid off. Repeat this process until you are debt-free. Research has shown that this method?-- "the snowball method"?-- can be the most effective way to pay off debt for many people, because it feels great to close out a balance. But if you are carrying debt with a sky-high interest rate, you might wish to focus on paying it off first to prevent overpaying in interest (the "avalanche" method). Whichever method you choose, making a plan can make it happen.

2. Dip into your savings.

It is smart to have extra cash in reserve, and you should not deplete your emergency savings fund. Yet, it also is senseless to have money in the bank earning a return of less than 1 percent while credit card companies are charging 15 percent interest or more on your debt. In these circumstances, using a portion of your savings to pay off a high-interest card can be a good move.

3. Reduce expenses.

Comb through your monthly expenses and look for ways to save dollars. Can you split the cost of gas and carpool to work? Make your coffee and lunch at home and forego the drive-through? Scrutinize your utility bills to see what extra services you can live without, such as caller identification or specialty cable channels. Start differentiating wants from needs, and the savings can add up dramatically.

4. Negotiate with creditors.

Talk to your creditors about your financial situation to see if you can reduce your interest rate, minimum payment or both. See if they will match any lower-interest offers that you may have received from other credit card companies. Most creditors would rather work out payment plans than lose money completely. They also don't want you to take your business to another creditor.

5. Get help if you need it.

If you realize you absolutely cannot pay your debt by yourself, now is the time to get help. Depending on your individual situation, you might benefit from a consumer credit advocacy firm that can advise on the debt relief options.?

- Debt management plans, which credit counseling firms offer, speed up the time it takes to get out of debt by lowering interest rates, but there are some drawbacks. You will no longer be able to use the credit accounts. You will most likely pay an enrollment fee and monthly fees. These plans do not lower total principal due.

- Debt settlement plans reduce principal balances due. They can sometimes reduce total unsecured debt owed by almost half. But because you do not make payments directly to creditors while you go through this process, delinquencies can appear on your credit report, which lower your credit score. You also may receive calls from creditors. Reputable firms should not charge you a fee until after they have finalized a settlement for you, and should help you through the process.

- Bankruptcy, generally viewed as a last resort, may be helpful for those in very serious debt situations for whom debt relief services cannot be of help. Be sure to discuss with a bankruptcy attorney licensed in your state.

If you cannot wipe the financial slate clean before the start of the New Year, you can feel better knowing that you are on the right track. Keep it up. Do not allow yourself to get so caught up in the holidays that you revert back to bad spending habits. This is the best gift you can give yourself.?
?

Source: http://chagrinfalls.woio.com/news/holiday/83910-how-ditch-your-debt-holidays

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Wednesday, October 24, 2012

Even the losers keep a little bit of pride (Unqualified Offerings)

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Director of Digital Communications-American World Jewish Service

Location:
New York

Organization:
Inspired by Judaism?s commitment to justice, American Jewish World Service?(AJWS)?works to realize human rights and end poverty in the developing world.

Position Description:
AJWS is seeking a digital leader to develop and build an integrated global digital presence to advance its mission, vision, programmatic work, advocacy campaigns and fundraising efforts. The director of digital communications will report to the vice?president for communications and manage a growing team of digital professionals, including staff dedicated to AJWS?s Website, social media, and e-mail campaigns. He or she will lead and execute a redesign of AJWS?s Website, all digital communication to AJWS?s many audiences, social media and marketing efforts. The director of digital communications will collaborate with the directors of national advocacy and campaigns to create dynamic national campaigns and messaging platforms. He or she will work with the entire communications team and AJWS staff in cities across the country to ensure that AJWS?s brand identity and messages are presented consistently and effectively across all platforms, including non-digital media and outlets. The director of digital communications will serve as a leader at AJWS and will proactively assess and adopt emergent technologies and strategies and develop new programs accordingly. He or she will need to function as a strategist, implementer, manager and ambassador for AJWS among digital professionals and networks. Finally, the director of digital communications must be committed to achieving measureable results and hold her/himself and her/his team accountable for producing them.

Responsibilities:
The Director of Digital Communications will:

  • Lead the strategy, execution and implementation of all digital communications for AJWS, including building and managing a growing team.
  • Work closely with the vice president for communications to ensure an integrated and strategic approach to all aspects of AJWS?s digital presence.
  • Oversee and manage a complete Website redesign and all content and functioning of the Website thereafter, collaborating with internal stakeholders to create effective Web communications.
  • Oversee the management of all social media initiatives, ensuring that AJWS?s social media efforts are strategic, not duplicative, and function to expand key audiences.
  • Create and implement e-mail and Web campaigns to raise funds, engage supporters in advocacy and educate key audiences. This will include generating activist communications for national campaigns and collaborating to develop geographically specific communications strategies to build AJWS?s brand nationally.
  • Oversee all digital marketing efforts, including paid online media, search engine marketing, internal/external partnerships, etc.
  • Track and employ e-mail, Web and social marketing analytics to measure the impact of AJWS?s entire digital operation.
  • Increase visibility and traffic and expand AJWS?s base of donors and advocates.
  • Monitor and respond to emergencies and natural disasters in the developing world and design and manage AJWS?s online response.

Qualifications:

  • Minimum 5 years of experience in a senior management position in an advocacy or political campaign.
  • Minimum 3 years of digital campaign experience in political and advocacy communications.
  • Proven track record in growing Website traffic, social media followership, and e-lists.
  • Strong project management skills, including exceptional organizational skills and attention to details; ability to drive and manage projects from conception to completion.
  • Proven management experience and the ability to cultivate a high-functioning team, juggle multiple tasks under tight deadlines and meet schedules and assigned tasks in a timely manner.
  • Excellent writing, editing, proofreading and verbal communication skills.
  • Highly professional demeanor with strong interpersonal skills and judgment and a demonstrated ability to manage internal teams, contractors and consultants with emotional intelligence and good humor.
  • Capable of working well with a wide variety of personalities and leadership styles.
  • Creative, resourceful, flexible team player.
  • Strong analytical skills and data management experience.
  • Experience and facility with Raiser?s Edge, CRM and CMS platforms, including the ability to help AJWS transition from Convio to another CMS.
  • Knowledge of politics, advocacy, human rights, international development and the American Jewish community, a plus. Must possess a commitment to global justice and deep respect for other cultures.

How to Apply:
For immediate consideration, please forward your resume and cover letter to?opportunities@ajws.org?and indicate your name and ?Director of Digital Communications? in the subject line. Applications submitted without a personalized cover letter will not be considered.

We thank you for your interest in career opportunities with AJWS. Due to high volume, only those candidates selected for an interview will be contacted.

AJWS is an equal opportunity employer and provides competitive salaries and benefits.

Source: http://www.comnetwork.org/2012/10/director-of-digital-communications-american-world-jewish-service/

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Miesha Tate pushes for Zoila Gurgel to get better Bellator billing

Former Strikeforce bantamweight champion Miesha Tate is not afraid to speak her mind. Last week, she caused a stir when she said there are circumstances where it's acceptable for a man to hit a woman. This week, she's speaking up on behalf of Bellator flyweight champion Zoila Gurgel.

Despite holding a belt and fighting near her hometown, Bellator has placed Gurgel's non-title bout with Casey Noland on the untelevised undercard. For good reason, Tate was annoyed by this and tweeted Bellator president Bjorn Rebney.

Tate sent several more tweets like these and encouraged her followers to tweet Bellator and Bjorn Rebney until they put Gurgel on the main card. Rebney explained his reasoning to MMA Fighting.

"Zoila's been plagued by injury after injury over the last 19 months, having not fought since March, 2011," he wrote. "We felt that the best road back for her did not include rushing her into a major fight against one of the top-ranked women in the world. This is not a world title fight as it's made significantly north of the 115 weight limit where she holds our title. Depending on how Zoila feels and performs on Friday, we can then determine the next appropriate step back."

But that doesn't explain why a champion isn't on television. Brian Rogers is not in a "world title fight," nor is he part of the Bellator tournament bouts that will be aired, but he's on the televised card. When fellow champions Michael Chandler and Ben Askren fought non-title bouts, their fights were on the main card.

When Tate spoke on men hitting women who hit them first, she was railing against a double standard. It looks like she's still fighting one this week.

Source: http://sports.yahoo.com/blogs/mma-cagewriter/miesha-tate-pushes-zoila-gurgel-better-bellator-billing-163345831--mma.html

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Tuesday, October 23, 2012

Food and Drink : PurpleTravel.co.uk : What to order in Andorra

A guide to Andorra cuisine

While the cuisine in Andorra is often likened to the Catalan cuisine, with its added bonus of French flavours and unique cooking methods, it does deserve a category in its own right. The exclusively traditional, mountain-style gastronomy famed in the Pyrenees has been enriched in Andorra, with much more variety. Set between two countries well-known for their gastronomic products and reputation, you can expect to find hundreds of cheeses, wines, foie gras, Iberian ham, baby squid, piquant potatoes, octopus Galician style, and much more.

The region has cleverly married the best of these local products and traditional recipes with new techniques and experiences. While in the mountains, you can take a meal in a typical rural inn called a borda, and be welcomed warmly by hospitable staff and homely decor or you can try some haute cuisine in one of the many exclusive restaurants offering unique gastronomic experiences. Find your way round the menu with our guide to Andorran cuisine.

The status of escargots ? called, in Catalan, ?cargols? ? approaches that of national dish in Andorra. Snails are typically served as an appetiser and charred in wood or coal ovens, sometimes sauced, but usually kept plain.


Catalan spinach is particularly delicious in Andorra due to its mountainous location. At its simplest, it is sauteed greens with raisins and pine nuts and a little black pepper.
One of the most famous and popular dishes in Andorra is Trinxat, which is basically an alpine take on ?bubble and squeak?. As is the standard in a mountainous climate, the locals learned to make the most of what crops grow best on poor soil and at altitude, so potato frequently features in Andorran dishes. Equally, so does pork, as the mountainous landscape also means that grazing land for cattle is at a minimum. Trinxat, meaning chopped in Catalan, is then a hearty mash of potatoes and cabbage, fried in a skillet-sized cake and garnished with fat back or smoky bacon.
The most surprising thing about Andorran food is the emphasis on seafood.Mountains always mean trout, so that?s a given, but the rest of the seafare on the menu seems more attuned to the coast than to the stream. Squid and octopus ? ?calamar i pop? ? are very popular, as are cod (?bacall??), and anchovies (?seitons?), the Atlantic staples.

Source: http://blog.purpletravel.co.uk/2012/10/23/what-to-order-in-andorra/

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Construction Industry Business: You Need To Know About Payday ...

Payday loans are short term loans intended to cover the cost of the client before coming payday. Guidelines on payday loans may vary widely between different countries. The normal process is that lenders loan stock unguaranteed short-term loans to be paid back to the customer's next paycheck. Usually, some confirmation of employment or income is involved but some loan providers may ignore this.

Payday loans can be acquired by anyone, even people with bad credit history. However, keep in mind that payday loans are meant to be paid back in no time. Online payday loans are that you receive a payday advance just to submit via the internet before you receive your paycheck. Once you have received your next pay check you are expected to pay back your loan.

Make the amount of money you can receive as a payday loans depends on how much salary you have. If you have a high income you have a greater chance each given a higher payday loans. The number of payday loans is entirely dependent on your income because that is what will determine whether or not you'll be able to pay back your loan and in what amount of time. Because payday loans are meant to be paid back in a short amount of time, it is important for companies that they do not lend more money than a person would be able to pay the employees their next payday.

Source: http://tijelada.blogspot.com/2012/10/you-need-to-know-about-payday-loan.html

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Monday, October 22, 2012

How to kill time without staring at your phone

7 hrs.

Once upon a time, standing around and waiting involved exactly that: Standing around, waiting, and not doing much else. Today, any free moment is spent facedown in a phone. Stop reading this on your own phone. Right now. Look around. At this moment, you should be the only person, anywhere in sight, not looking at a phone.

But staring at that phone isn't the only way to wait. You can do other stuff. In fact, there are exactly six things you can do instead.

Make eye contact
People used to do this all the time. You could recognize a neighbor or share a moment with an attractive stranger. It can still happen???but you have to be careful. You don't want to be caught staring right at the moment that person looks up from his (or especially her) phone. Wait until the fleeting few seconds when this person looks away from the phone for some reason, then casually lock eyes. Smile! It will seem a lot less weird that way. When you get back online, this kind of encounter is a great thing to put on Craigslist as a Missed Connection.

Talk about the weather
This is a classic. If you're new at it, try some established introductory phrases.

  • "This is some rain!"
  • "Hot enough for ya?"
  • "They say it's gonna turn cold tomorrow!"

For this to work, you'll need a little luck, because you have to find someone else who is also not looking at a phone. Otherwise, there's a data-filled weather app just a tap away. Not to mention that look:?Why are you talking to me, can't you see I'm looking at my phone?

Observe your surroundings
If you look up from your phone for long enough, you can notice amazing things happening all around you. A pigeon pecking at a pizza crust. A man pushing a shopping cart piled higher than his head. A grown woman weeping hysterically. That's real life! And it is stunning. Once you get back on your phone, all of these observations will make excellent tweets.

Find unusual patterns
This one is a bit of a brain teaser. Look over at that odd brick wall, or the hexagonal tile on the floor, or that way the ice cubes collect at the bottom of your glass. Gaze into these shapes. Watch them form new shapes. See the shapes begin to arrange themselves, rotating, and falling into position. So chaotic, yet so organized. You know what? This calls for a quick game of "Tetris."

See what other people are looking at on their phones
This is an endlessly fascinating sociological exercise, and it can also give you fresh ideas about what you could be doing on your own phone. A scouting report from a recent bus ride:

  • Shiny gold case. Hot pink case. iPhone 5, no case.
  • Cracked white iPhone 4 with an incoming call from "Daddy."
  • Bedazzled lady playing "Bedazzled."
  • Woman urgently speaking Spanish into a white Nokia with gold trim.
  • Girl on an HTC, reading Gawker, followed by "A Farmer's Market, Deep in China."

You could also just read a book
But then you're not even thinking about looking at your phone. You're looking at your Kindle.

This is what I do, anyway???how do you kill time phone-free?

More from Gizmodo:

Opening photo: Four guys who really know how to look at phones. From left:?Jesus Diaz,?Matt Buchanan,?Sam Biddle, and?Matt Hardigree. Shot by?John Mahoney.

Source: http://www.nbcnews.com/technology/gadgetbox/how-kill-time-without-staring-your-phone-1C6583331

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Miguel Cabrera gets in his licks, and his laughs

Associated Press Sports

updated 1:25 p.m. ET Oct. 21, 2012

(Eds: APNewsNow. With AP Photos.)

DETROIT (AP) - When comedian George Lopez showed up at a Detroit Tigers workout Friday, Miguel Cabrera was one of the most excited players on the team.

No surprise there. Baseball's first Triple Crown winner in 45 years seems to enjoy hitting and laughing in equal proportion.

Fans are plenty familiar with Cabrera's talent - his consistently high batting average and awe-inspiring power. But his Detroit teammates appreciate him for more than that. Cabrera may be a bit shy in front of a camera or microphone, but there's a goofy side to the third baseman that helps keep his team loose.

Now in the prime of his career, Cabrera's approach remains meticulous, but he's careful not to take himself or his job too seriously.

? 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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Giants, Cards prepare for Game 6

HBT: St. Louis, with Chris Carpenter on the mound, hopes to close out the NLCS on Sunday when the series moves to S.F. Ryan Vogelsong will get the start for the Giants.

Source: http://nbcsports.msnbc.com/id/49495173/ns/sports-baseball/

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Aggressive brain tumors can originate from a range of nervous system cells

ScienceDaily (Oct. 22, 2012) ? Scientists have long believed that glioblastoma multiforme (GBM), the most aggressive type of primary brain tumor, begins in glial cells that make up supportive tissue in the brain or in neural stem cells. In a paper published October 17 in Science, however, researchers at the Salk Institute for Biological Studies have found that the tumors can originate from other types of differentiated cells in the nervous system, including cortical neurons.

GBM is one of the most devastating brain tumors that can affect humans. Despite progress in genetic analysis and classification, the prognosis of these tumors remains poor, with most patients dying within one to two years of diagnosis. The Salk researcher's findings offer an explanation for the recurrence of GBM following treatment and suggest potential new targets to treat these deadly brain tumors.

"One of the reasons for the lack of clinical advances in GBMs has been the insufficient understanding of the underlying mechanisms by which these tumors originate and progress," says Inder Verma, a professor in Salk's Laboratory of Genetics and the Irwin and Joan Jacobs Chair in Exemplary Life Science.

To better understand this process, Verma's team harnessed the power of modified viruses, called lentiviruses, to disable powerful tumor suppressor genes that regulate the growth of cells and inhibit the development of tumors. With these tumor suppressors deactivated, cancerous cells are given free rein to grow out of control.

To do that, Verma and his colleagues attached small RNA molecules, known as short hairpin RNAs, to the modified viruses and injected them directly into very few cells in the brains of genetically engineered mice that express an enzyme known as CRE specifically in neurons, astrocytes or neural stem cells. The modified viruses target two genes -- -neurofibromatosis 1 (NF1) and p53 -- -that, when mutated, are implicated in severe gliomas like GBM. Using sophisticated analytical techniques, they discovered that neurons genetically converted by the lentiviruses that also produce green fluorescent protein (GFP) as a marker to track the progression of tumors are capable of forming malignant gliomas.

Because the origin of glioblastomas from neurons has not been previously reported, the Salk scientists provided further evidence that mature neurons can be transformed by these oncogenes by isolating cortical neurons from genetically engineered mice and transducing them with one of the lentiviruses. The neurons that were transplanted back into the mice developed the same tumors as the ones in the laboratory.

"Our findings," says lead author Dinorah Friedmann-Morvinski, a postdoctoral researcher in the Laboratory of Genetics, "suggest that, when two critical genes -- -NF-1 and p53 -- -are disabled, mature, differentiated cells acquire the capacity to reprogram [dedifferentiate] to a neuroprogenitor cell-like state, which can not only maintain their plasticity, but also give rise to the variety of cells observed in malignant gliomas."

If scientists can block the process of dedifferentiation or proliferation of dedifferentiated neuroprogenitor cells, they may be able to stop tumor progression. That's important in an aggressive disease like GBM because of its high rate of recurrence.

"Our results offer an explanation of recurrence of gliomas following treatment," says Verma, "because any tumor cell that is not eradicated can continue to proliferate and induce tumor formation, thereby perpetuating the cycle of continuous cell replication to form malignant gliomas."

The scientists say the tumors in their mouse model are similar to GBMs that affect humans. Because they have the same pathology and characteristic genetic signature, scientists can study potential therapies in mice that should, theoretically, work in humans. While they may not eradicate GBM, these therapies may slow the progression of the disease and improve patients' quality of life.

Other researchers on the study were Eugene Ke, Yasushi Soda, Tomotoshi Marumoto and Oded Singer of the Salk Institute; and Eric Bushong and Mark Ellisman of the University of California, San Diego.

The work was supported by the National Institutes of Health, Ipsen/Biomeasure, the Leona M. and Harry B. Helmsley Charitable Trust, the H.N. and Frances C. Berger Foundation, and the National Center for Research Resources.

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Story Source:

The above story is reprinted from materials provided by Salk Institute for Biological Studies, via Newswise.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. D. Friedmann-Morvinski, E. A. Bushong, E. Ke, Y. Soda, T. Marumoto, O. Singer, M. H. Ellisman, I. M. Verma. Dedifferentiation of Neurons and Astrocytes by Oncogenes Can Induce Gliomas in Mice. Science, 2012; DOI: 10.1126/science.1226929

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/FmwsERG8M9g/121022162341.htm

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Sunday, October 21, 2012

WHY IT MATTERS: Race

The issue:

The nation's complexion is rapidly changing. A more racially and ethnically diverse population is rising so that, perhaps within three decades, whites will no longer be the majority. That means shifts in political power, the risk of intensified racial tensions and also the opportunity to forge a multiracial society unlike anything in America's past.

___

Where they stand:

Nearly half a century after the signing of the Civil Rights Act, America elected its first black president in 2008. President Barack Obama says that milestone alone changed attitudes on race, yet "I never bought into the notion that by electing me, somehow we were entering into a postracial period." He's trod carefully on matters of race, in some minds too carefully, in favor of a rising-tide-lifts-all-boats philosophy.

Mitt Romney appears to favor the melting-pot ideal more than the mosaic, envisioning a future in which Americans put aside cultural differences grounded in race and ethnicity to stand as one people. A gulf remains, though, between minorities and the Republican Party as blacks and Latinos in particular continue to see their interests better represented by Democrats. Hispanic Republicans are making striking inroads in state politics; nationally, it's a different story. GOP immigration policy alone has been taken as a sign of hostility.

___

Why it matters:

The U.S. hit a historic benchmark when the census announced in May that a majority of children younger than 1 ? 50.4 percent ? were minorities. The fast growth in minority populations is due largely to increases in Latino births and high immigration. Hispanics are the most populous minority group, numbering 52 million last year (and representing close to 17 percent of the population). The census put the black population at 43.9 million and Asians the third largest minority group at 18.2 million.

Meanwhile, the white population in the 100 largest metro areas dropped to 57 percent from 71 percent over the last 20 years, according to the Brookings Institution. Demographers predict minorities might become the majority by 2042, although slowdowns in growth in the Asian and Hispanic populations could delay that. Minorities now make up more than 36 percent of the U.S. population.

The shift means a change in the needs of the overall U.S. population and in backgrounds.

Unemployment is higher among blacks and Latinos, as is the lack of health insurance. Latino children have higher rates of poverty. More black men are in America's prisons; many Latinos are grappling with deportation of family members.

The economic and housing crises hit black and Latino communities harder.

U.S. minority populations are younger, which means they will be a big share of the workforce for years to come and a growing force at the ballot box.

Obama's election in 2008 underscored the nation's racial gulf in politics even as it made history. He was elected with 96 percent of the black vote, 67 percent of the Hispanic vote and about 43 percent of the white vote.

Minorities increasingly will influence elections if their turnout keeps rising and the pool of voters keeps growing. It's certain minorities will want to see more people in office who look like them, understand their needs and in some cases speak their language. Communities are grappling with new populations and cultures in places far removed from America's usual centers of multiethnic life.

The next president, black or white, has no choice but to keep matters of race and equality on his agenda.

EDITOR'S NOTE _ One in a series examining issues at stake in the election and their impact on people

Source: http://news.yahoo.com/why-matters-race-133923555--election.html

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Armstrong says last few weeks 'difficult'

AUSTIN, Texas (AP) ? Lance Armstrong greeted about 4,300 cyclists at his Livestrong charity's fund-raiser bike ride Sunday, then retreated into privacy as cycling officials get set to announce if they will appeal his lifetime ban and loss of seven Tour de France titles ordered by the U.S. Anti-Doping Agency.

Armstrong spoke briefly at the sunrise start of the ride, telling the crowd he's faced a "very difficult" few weeks. But he did not otherwise mention USADA's report detailing evidence of performance-enhancing drug use by Armstrong and his teams or the sanctions.

International Cycling Union (UCI) President Pat McQuaid has scheduled a Monday news conference in Geneva where he's expected to announce if the sport's governing body will accept or appeal the sanctions to the Court of Arbitration for Sport.

"I've been better, but I've also been worse," Armstrong, a cancer survivor, told the crowd, repeating a line from his remarks at Livestrong's 15th anniversary celebration Friday night.

Armstrong wore a black t-shirt instead of the charity's signature yellow derived from the yellow jerseys given to the winner of the Tour de France.

"Live strong, be safe," Armstrong said before the first riders left the gate.

Armstrong stepped down as chairman of Livestrong on Wednesday. That same day, most of his personal sponsors, including Nike and brewing giant Anheuser-Busch, dropped their contracts with him or said they would not renew when current deals expire.

USADA has said Armstrong should be banned and stripped of his Tour de France his titles for what the agency called "the most sophisticated, professionalized and successful doping program that sport has ever seen" within his U.S. Postal Service and Discovery Channel teams.

The USADA report said Armstrong and his teams used steroids, the blood booster EPO and blood transfusions. The report included statements from 11 former teammates who testified against Armstrong.

Armstrong denies doping, pointing to hundreds of passed drug tests. But he chose not to fight USADA in one of the agency's arbitration hearings, saying the process was biased against him. Former Armstrong team director Johan Bruyneel is also facing doping charges, but he is challenging the USADA case in arbitration.

Tour de France director Christian Prudhomme is waiting on the UCI's decision before removing Armstrong's name from the record books as the race prepares to celebrate its centenary edition next year.

Armstrong won consecutive Tours from 1999-2005. Prudhomme said the Tour will have no official winners for the seven races Armstrong won if he is stripped of his victories by the UCI.

USADA has said the Tour titles should not be given to other riders who finished on the podium. The agency said 20 of the 21 riders on the podium in the Tour from 1999 through 2005 have been "directly tied to likely doping through admissions, sanctions, public investigations" or other means. It added that of the 45 riders on the podium between 1996 and 2010, 36 were by cyclists "similarly tainted by doping."

Several riders at Sunday's event, which organizers said raised $1.7 million, said they support Armstrong completely or separate his cycling career from his charitable work. Livestrong has raised about $500 million to fight cancer and support victims since it was founded in 1997.

"If he did it, he should face the consequences," said Sonya Garrison, who was riding in memory of her grandfather and to support a friend with cancer. "But this is for the cause. More people are here for the cause than just for him."

Rider Steve Weinberg said he's "still a Lance fan" regardless of the doping charges.

"I think everyone was doing it back then," Weinberg said, noting Armstrong's passed drug tests. "That whole thing needs to go away."

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2012-10-21-Armstrong-Doping/id-6748c5319a7c443e9386a868ece7f7b0

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WHY IT MATTERS: Issues at stake in election

A selection of issues at stake in the presidential election and their impact on Americans, in brief:

Abortion:

Abortion and birth control are divisive issues in politics, and they've flared up at times in this campaign despite the candidates' reluctance to dwell on them.

President Barack Obama supports abortion rights. And his health care law requires contraceptives to be available for free for women in workplace health plans.

Republican Mitt Romney opposes abortion rights, though he previously supported them. He says the Supreme Court ruling establishing abortion rights should be reversed, allowing states to ban abortion. He's also criticized mandatory coverage for contraception as a threat to religious liberty.

Romney's ability as president to enact federal abortion restrictions would be limited unless Republicans gained firm control of Congress. But the next president could have great influence over abortion policy if vacancies arise on the Supreme Court. If two seats held by liberal justices were filled by Romney-nominated conservatives, prospects for a reversal of Roe v. Wade would increase.

___

Afghanistan:

The stakes now are similar to what caused the U.S. to invade almost 11 years ago: the threat of more al-Qaida attacks.

Obama says U.S. forces must not leave until Afghan forces can defend the country on their own. Otherwise the Taliban would regain power and al-Qaida might again launch attacks from there. Rival Romney appears to share that view.

What's often overlooked in the "al-Qaida returns" scenario is an answer to this question: Why, after so many years of foreign help, are the Afghans still not capable of self-defense? And when will they be?

The official answer is by the end of 2014, when the U.S. and its allies plan to end their combat role. The Afghans will be fully in charge, or so it is hoped, and the war will be over, at least for Americans.

___

Auto bailout:

There's little doubt the government bailout of General Motors and Chrysler kept the automakers afloat and saved huge numbers of jobs. But there's also little chance the government will get all its money back.

Taxpayers are out about $1 billion on the Chrysler rescue. GM stock is selling for less than half the price needed for the government to recover all of its nearly $50 billion investment in that company.

Obama carried forward a bailout begun by his predecessor. Romney opposed it. He said the companies should have gone through a private restructuring, with certain government guarantees after they reorganized.

Three years later, both companies are profitable. Chrysler has added almost 12,000 workers; GM, about 2,000. It's been estimated that 1 million jobs have been saved at automakers, parts companies and related businesses.

___

Campaign finance:

This election probably will cost more than $1 billion. Big donors who help cover the tab could gain outsized influence with the election's winner. Your voice may not be heard as loudly as a result.

Recent court decisions have stripped away restrictions on how elections are financed, allowing the very rich to afford more speech than the rest. In turn, super PACs have flourished, thanks as well to limitless contributions from the wealthy ? including contributors who have business before the government.

Disclosure rules offer a glimpse into who's behind the money. But the information is often too vague to be useful. And nonprofits that run so-called issue ads don't have to reveal donors.

Obama criticized the Supreme Court for removing campaign finance restrictions. Romney supported the ruling. Both are using the lax rules with gusto.

___

China:

The U.S. accuses China of flouting trade rules and undervaluing its currency to helps its exporters, hurting American competitors and jobs. But imposing tariffs could set off a trade war and drive up prices for American consumers.

Tensions now have spread to the automotive sector: The U.S. is seeking international rulings against Chinese subsidies for its auto and auto-parts exports and against Chinese duties on U.S. autos. Romney says he'll get tougher on China's trade violations. Obama has taken a variety of trade actions against China, but on the currency issue, he has opted to wait for economic forces to encourage Beijing to raise values.

Cheap Chinese goods have benefited American consumers and restrained inflation. But those imports have hurt American manufacturers. And many U.S. companies outsource production to China. One study estimated that between 2001 and 2010, 2.8 million U.S. jobs were lost or displaced to China.

___

Civil rights:

What, exactly, is discrimination, and what should be done to fight it? This election offers choices on the answer.

In areas such as mortgages, voter identification and immigration enforcement, the presidential candidates differ over how to use laws that guarantee equality and how far the Justice Department's civil rights division should go to ensure all Americans are treated fairly.

The election also will shape the Justice Department's actions in continuing court cases that challenge voter ID laws passed in some Republican-led states. Opponents contend such laws unfairly discourage minority voting.

Under Obama, the government has aggressively prosecuted cases where statistics show that blacks and Hispanics are hit harder than whites. Under recent Republican presidents, the Justice Department has limited its enforcement to cases with evidence of intentional discrimination ? not where statistics show that minorities were broadly disadvantaged by a particular practice.

___

Climate change:

This year America's weather has been hotter and more extreme than ever before, records show. Yet the presidential candidates aren't talking about it.

In the U.S. July was the hottest month ever recorded, and this year is on track to be the warmest. Scientists say that's both from natural drought and man-made global warming. Each decade since the 1970s has been nearly one-third of a degree warmer than the previous one.

Sea levels are rising while glaciers and summer Arctic sea ice are shrinking. Plants are blooming earlier. Some species could die because of global warming.

Obama proposed a bill to cap power plant carbon dioxide emissions, but it died in Congress. Still, he's doubling auto mileage standards and put billions into cleaner energy. Romney now questions the science of man-made global warming and says some actions to curb emissions could hurt an already struggling economy.

___

Cybersecurity:

The risk of a devastating cyberattack on the United States is real. Yet the country remains vulnerable to an electronic Pearl Harbor due to a political dispute over the role the federal government should play in securing the computer networks that control the electrical grid, water supply and other critical sectors.

Obama wants the owners of essential U.S. infrastructure to meet minimum cybersecurity standards. But Republicans in Congress say the president's approach will only lead to costly, time-consuming regulations that won't reduce the risk. Romney says Obama has failed to lead on a critical national security issue.

While Congress bickers, the Pentagon worries. "The uncomfortable reality of our world today is that bits and bytes can be as threatening as bullets and bombs," Gen. Martin Dempsey, the chairman of the Joint Chiefs of Staff, told lawmakers.

___

Debt:

A sea of red ink is confronting the nation and presidents to come.

The budget deficit ? the shortfall created when the government spends more in a given year than it collects ? has topped $1 trillion for a fourth straight year. The government borrows about 31 cents for every dollar it spends.

The national debt is the total amount the federal government owes. It's risen to a shade over $16 trillion.

Obama has proposed bringing deficits down by slowing spending gradually, to avoid suddenly tipping the economy back into recession. He'd raise taxes on households earning more than $250,000 and impose a surcharge of 30 percent on those making more than $1 million. Romney would lower deficits mostly through deep spending cuts. But many of the cuts he's pushing would be partially negated by his proposals to lower top tax rates on corporations and individuals.

___

Defense spending:

At its core, the debate over how much the U.S. spends on defense gets down to this: What is it that America should be defending against?

There are plenty of potential security threats on the horizon, not to mention an unfinished war in Afghanistan.

The size and shape of the defense budget go a long way toward determining whether the U.S. can influence events abroad, prevent new wars and be ready for those it can't avoid. It also fuels the domestic defense industry in ways that affect the vitality of communities large and small across the country.

Obama wants more restraint in military spending while Romney favors expansion. Obama also wants more focus on Asia-Pacific security, reflecting China's military modernization. But that and other elements of military strategy could come apart if Washington doesn't find a way to avoid automatic budget cuts starting in January.

___

Economy:

The job market is brutal and the economy weak. More than 12 million Americans can't find work; the unemployment rate fell in September but is still at a recession-level 7.8 percent. It had been more than 8 percent for 43 straight months. A divided Washington has done little to ease the misery.

The economy didn't take off when the recession ended in June 2009. Growth has never been slower in the three years after a downturn. The human toll is staggering. Forty percent of the jobless, 4.8 million people, have been out of work six months or more ? a "national crisis," according to Federal Reserve Chairman Ben Bernanke. Wages aren't keeping up with inflation.

Obama wants to create jobs by keeping taxes low for everybody but the wealthiest and with public-works spending, clean energy projects and targeted tax breaks to businesses. Romney proposes further cuts in tax rates for all income levels; he'd also slash corporate rates, reduce regulations and encourage oil production.

___

Education:

Education ranks second only to the economy in issues important to Americans. Yet the U.S. lags globally in educating its children. And higher education costs are leaving students saddled with debt or unable to afford college at all.

State budget cuts have meant teacher layoffs and larger class sizes. Colleges have had to make do with less. It all trickles down to the kids in the classroom.

Although Washington contributes a small fraction of education money, it influences teacher quality, accessibility and more. For example, to be freed from provisions of the No Child Left Behind law, states had to develop federally approved reforms.

Romney wants more state and local control over education. But he supports some of Obama's proposals, notably charter schools and teacher evaluations. So, look for them to be there whoever wins the White House.

___

Energy:

American energy is booming and that's got consequences for the economy and the environment.

Obama embraces both traditional and renewable energy sources. He's spent billions on "green energy" and backs a tax credit for the wind industry that Romney opposes. Romney pledges to make the U.S. independent of energy sources outside of North America by 2020, through more aggressive exploitation of domestic oil, natural gas, coal and more, and approval of the Keystone XL pipeline from Canada.

U.S. dependence on imported oil has declined because of the economic downturn, improved efficiency and changes in consumer behavior. Production of all types of energy has increased, spurred by improved drilling techniques and discoveries of vast oil supplies in North Dakota and natural gas in states such as Pennsylvania, Ohio, New York and West Virginia.

Critics, though, worry that hydraulic fracturing and horizontal drilling could harm air, water and health.

___

Environment:

If Obama wins re-election, he could get a second wind on environmental regulations that were delayed in his first term. A Romney presidency is likely to roll back what Republicans consider excessive and expensive rules.

Obama achieved historic increases in fuel-economy standards and imposed the first regulations on heat-trapping gases blamed for global warming. His administration tightened standards on mercury pollution from power plants and set new controls on soot.

But he couldn't persuade a Democratic Congress to pass limits he promised on carbon emissions and shelved a plan to toughen health standards on lung-damaging smog.

Romney questions the cause of climate change and he's criticized Obama's treatment of coal-fired power plants. He opposes treating carbon dioxide as a pollutant and wants the cost of complying with regulations given more consideration.

___

European economic crisis:

Europe is struggling to control a debt crisis, save the euro currency and stop a repeat of the 2008 financial crisis that sent the world into recession.

Europe's troubles are the No. 1 threat to the U.S. economy. The biggest fear is that the 17-country eurozone will split, causing a financial crisis that will spread across the Atlantic, freeze credit and send the U.S. economy back into recession.

Neither Obama nor Romney has offered plans for Europe. The U.S. government lacks the cash and the will to rescue European countries struggling with huge government debts.

Obama has urged Europe to act more decisively. Romney warns that the United States will face its own day of reckoning if it can't reduce the federal debt. Many economists call for eurozone countries to assume joint responsibility for the weakest countries' debts through eurobonds; Germany has balked at the idea.

___

Gay marriage:

Both sides of the gay marriage debate agree on this much: The issue defines what sort of nation America will be.

Half a dozen states and the District of Columbia have made history by legalizing it, but it's prohibited elsewhere and 30 states have placed bans in their constitutions.

Obama supports legal recognition of same-sex marriage, as a matter decided by states. Romney says same-sex marriage should be banned with a constitutional amendment.

The debate divides the public down the middle, according to recent polls, and stirs up passion on both sides.

In November, four states have gay-marriage measures on their ballots. In Minnesota, the vote is whether to ban gay marriage in the state constitution. Voters in Maine, Maryland and Washington state are voting on whether to legalize gay marriage.

Thus far, foes of gay marriage have prevailed in all 32 states where the issue reached the ballot.

___

Guns:

Gun violence has been splayed across front pages with alarming frequency lately: the movie theater killings in Colorado, the Sikh temple shootings in Wisconsin, the gunfire outside the Empire State Building and more. Guns are used in two-thirds of homicides, according to the FBI. But the murder rate is less than half what it was two decades ago.

Neither Obama nor Romney has had much to say about guns during the campaign. Obama hasn't pushed gun control measures as president; Romney says new gun laws aren't needed.

It's getting harder to argue that stricter gun laws are needed when violent crime has fallen by 65 percent since 1993.

But the next president may well fill at least one Supreme Court seat, and the court is narrowly divided on gun control. An Obama appointee could be expected to be friendlier to gun controls than would a Romney nominee.

___

Health care:

America's health care system is unsustainable. It's not one problem, but three: cost, quality and coverage.

The U.S. has world-class hospitals and doctors. But it spends far more than other advanced countries and people aren't much healthier. And in an aging society, there's no reliable system for long-term care.

Obama's expansion of coverage for the uninsured hits high gear in 2014. Obama keeps today's Medicare while trying to slow costs. He also extends Medicaid.

Romney would repeal Obama's health care law but hasn't spelled out what he'd do instead. On Medicare, he favors the option of a government payment to help future retirees get private coverage.

The risk of expanding coverage: Health costs consume a growing share of the stressed economy. The risk of not: Millions continue uninsured or saddled with heavy coverage costs as the population grows older.

___

Immigration:

An estimated 11.5 million illegal immigrants are living and often working in the United States. Figuring out what to do with them has confounded Washington for years.

Lax enforcement could mean more illegal immigrants competing with citizens and legal immigrants for jobs and some social services. A too-tight policy could mean farmers and others in industries that rely on the cheaper labor of illegal immigrants are left begging for workers, passing higher costs on to everyone else or going out of business.

Obama backed the DREAM Act, a failed bill that would have provided a path to legal status for many young illegal immigrants. In June, Obama decided to allow as many as 1.7 million of them to stay for up to two years. Romney has said he would veto the DREAM Act, though during the second presidential debate he said he supports a path to legal status for young illegal immigrants. He would honor any work permits issued under Obama's plan to delay deportations for many young illegal immigrants but wouldn't accept new applications for the programs.

___

Income inequality:

The income gap between the rich and everyone else is getting larger, while middle incomes stagnate. That's raised concerns that the middle class isn't sharing in economic growth as it used to.

Obama would raise taxes on households earning more than $250,000 a year, plus set a minimum tax rate of 30 percent for those earning $1 million or more. He also wants to spend more on education, "a gateway to the middle class." Romney would cut taxes more broadly and says that will generate enough growth to raise all incomes.

Income inequality has risen for three decades and worsened since the recession ended. The Census Bureau found the highest-earning 20 percent earned 51.1 percent of all income last year. That was the biggest share on records dating to 1967. The share earned by households in the middle 20 percent fell to 14.3 percent, a record low.

___

Infrastructure:

Much of America's infrastructure ? the interstate highway system, mass transit networks and more ? is well-over half a century old and in need of serious repair and modernization. System breakdowns and bottlenecks are slowing commerce, at a cost to the economy and America's global competitiveness. The World Economic Forum put the U.S. 24th last year in the quality of its infrastructure, down from fifth in 2002.

The dilemma facing any president is how to maintain critical public works when budgets are crippled. Both candidates say infrastructure is important. The divide is over how to pay for it, and which projects.

Obama has favored stimulus-style spending and pushed for innovations like high-speed rail. Romney favors less federal involvement. He also shuns the idea that public-works spending is a good way to jumpstart the economy, saying decisions on projects should be based on need and potential returns.

___

Iran:

With the Iraq war over and Afghanistan winding down, Iran is the most likely place for a new U.S. military conflict.

Obama says he'll prevent Iran from acquiring nuclear weapons. He hopes sanctions alongside negotiations can get Iran to halt uranium enrichment. But the strategy hasn't worked yet. Obama holds out the threat of military action as a last resort.

Romney accuses Obama of being weak on Iran. He says the U.S. needs to present a greater military threat.

Attacking Iran is no light matter, however. That is why neither candidate clearly calls for military action.

Tehran can disrupt global fuel supplies, hit U.S. allies in the Gulf or support proxies such as Hezbollah in acts of terrorism. It could also draw the U.S. into an unwanted new war in the Muslim world.

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Israel:

As concern intensifies over Iran's nuclear program and the rise of Islamist governments in the Middle East, America's top ally in the region, Israel, has become increasingly wary. Israel's security has been a U.S. foreign policy priority of both Democratic and Republican administrations since the Jewish state was created in 1948.

Although small, Israel has significant influence in Washington and presidents of both parties have pledged their commitment to its defense. And it's always a potential flashpoint in a region that the U.S. depends on for oil.

Obama has continued the strong support for Israel. Both American and Israeli officials say security cooperation is as strong as it has ever been. But the Obama administration has become embroiled in several very public spats with Benjamin Netanyahu's government.

Romney sharply criticizes Obama's policy on Israel. He's friendly with Netanyahu, visited Israel in July and vows unreserved U.S. support.

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Labor:

Unions have long been viewed as a way for workers to gain job protections, boost wages and benefits and live a middle-class life. But organized labor has been in a tailspin for decades, losing millions of members and the influence it once wielded in the workplace.

About 14.8 million Americans are members of labor unions. That's just 11.8 percent of the workforce ? down from about a third of all workers in the 1950s.

The numbers have dropped as domestic manufacturing jobs go overseas and businesses take a tougher approach against union organizers.

Union leaders want Washington's help in making it easier to organize members and promote the use of union labor. They've had some success under Obama. But Romney says as president, he would reverse all of Obama's union-friendly executive orders. And he'd seek national right-to-work legislation prohibiting unions from collecting dues from nonmembers.

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Missile defense:

Missile technology is proliferating. It remains unclear how quickly foes like Iran and North Korea could develop a capability to reach the United States with missiles, but the U.S. says Iran is already able to hit allies in Europe.

The United States is spending nearly $10 billion a year on missile defense when military budgets are stretched. But the programs have yet to prove that they can reliably knock long-range missiles out of the sky.

The U.S. is deploying missile interceptors not only on home soil, but in Europe and Asia, drawing complaints from Russia and China. Moscow has said it will resist plans backed by both Obama and Romney. Romney has said he will not compromise with Russia on U.S. missile defense capabilities. And he opposes a missile-defense spending cut favored by Obama.

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Social Security:

Unless Congress acts, the trust funds that support Social Security are on pace to run out of money in 2033, triggering an automatic 25 percent cut in benefits that millions of older Americans rely on for most of their income.

That may seem far off. But the sooner Congress acts, the more time to phase in changes slowly.

Social Security could be preserved for generations with modest but politically difficult changes to benefits or taxes, or some of both.

Obama hasn't laid out a detailed plan for addressing Social Security. Romney proposes a gradual increase in the retirement age and, for future beneficiaries, slower growth in benefits for the wealthy.

But nothing will happen without White House leadership.

For millions of retired and disabled workers, Social Security is almost all they have to live on. Monthly retirement benefits are $1,237; average disability benefits, $1,111.

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Supreme Court appointments:

With four justices in their 70s, odds are good that whoever wins in November will fill at least one Supreme Court seat. The next justice could dramatically alter the direction of a court split between conservatives and liberals.

One new face could mean a sea change in how millions get health care, shape gay rights and much more.

Obama already has put his stamp on the court by selecting liberal-leaning Justices Elena Kagan and Sonia Sotomayor, 50-somethings who could serve a quarter-century or more. Romney has promised to name justices in the mold of the court's conservatives.

Since the New Deal, Supreme Court decisions have made huge differences in American lives, from rulings to uphold Social Security, minimum wage laws and other Depression-era reforms to ringing endorsements of equal rights. Big decisions on health care, gun rights and abortion have turned on 5-4 votes.

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Syria:

Syria's conflict is the most violent to emerge from last year's Arab Spring. The fighting has escalated into a civil war that has killed more than 33,000 people in the last 20 months, according to activists.

Obama wants Syrian President Bashar Assad to leave power. But he won't use U.S. military force to make that happen.

Romney says "more assertive" U.S. tactics are needed, without fully spelling them out.

The future of Arab democracy could hinge on the crisis. After dictatorships fell in Tunisia, Egypt, Libya and Yemen, critics say Assad's government has resorted to torture and mass killings to stay in power.

Assad's success would deny the U.S. a major strategic victory. He long has helped Iran aid Hamas and Hezbollah, destabilizing Lebanon while threatening Israel's security and U.S. interests in the Middle East.

But extremists among the opposition, Assad's weapons of mass destruction and worries about Israel's border security have policymakers wary about deeper involvement.

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Taxes:

Almost every U.S. taxpayer faces a significant tax increase next year, unless Congress and the White House agree on a plan to extend a huge collection of tax cuts expiring at the end of the year.

And there's a huge debate over how to overhaul the tax code to make it simpler, with lower rates balanced by fewer deductions.

Obama wants to extend Bush-era tax cuts again, but only for individuals making less than $200,000 and married couples making less than $250,000.

Romney wants to extend all those tax cuts and enact new ones, dropping all income tax rates by 20 percent. Romney says he would pay for that by eliminating or reducing tax credits, deductions and exemptions. But he won't say which ones would go.

Most lawmakers want a simpler tax code, but millions count on the mortgage interest deduction, child tax credit and more, making progress all but impossible.

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Wall Street regulation:

The debate over banking rules is, at its core, a dispute about how to prevent another economic cataclysm.

The financial crisis that peaked in 2008 touched off a global economic slowdown. Four years later, the recovery remains painfully slow.

After the crisis, Congress passed a sprawling overhaul of banking rules and oversight. The law gives regulators new tools to shutter banks without resorting to emergency bailouts. It restricts risky lending and establishes a new agency to protect consumers from misleading marketing and other traps.

The new rules also boost companies' costs, according to Romney and many in the business community. Romney believes the law is prolonging the nation's economic agony by making it harder for companies to invest and grow. He has pledged to repeal it. Obama fought for and supports the law.

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Associated Press writers Nancy Benac, David Crary, Tom Raum, Seth Borenstein, Robert Burns, Jack Gillum, Paul Wiseman, Carole Feldman, Mark Sherman, Matthew Pennington, Bradley Klapper, Ricardo Alonso-Zaldivar, Daniel Wagner, Stephen Ohlemacher, Alicia A. Caldwell, Christopher S. Rugaber, Jason Keyser, Sam Hananel, Desmond Butler, Richard Lardner, Tom Krisher, Jesse Washington, Matthew Daly and Matthew Lee contributed to this report.

EDITOR'S NOTE _ Part of a series examining issues at stake in the election and their impact on people

Source: http://news.yahoo.com/why-matters-issues-stake-election-160424306--election.html

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